Five people were killed and 20 others injured after a passenger bus collided head-on with a trailer near MM Road in Bhakkar.
Rescue teams shifted the injured to a nearby hospital. They are reported to be out of danger.
According to Rescue 1122, a woman and her daughter were among the deceased.
The bus was on its way to Mansehra from Karachi.
Police said the drivers of the two vehicles are being interrogated.