The National Accountability Bureau on Thursday approved inquiries against some former and sitting lawmakers as well as bureaucrats.
The inquiry was approved by NAB chairman Justice (retd) Javed Iqbal.
The NAB chief has approved filing of a corruption reference against former federal minister for Ports and Shipping Babar Ghori. Ghori is facing charges of more than 900 unlawful postings.
The anti-graft body has also ordered initiation of inquiries against former federal minister Khawaja Asif, former provincial irrigation minister of Sindh Zafar Ali Laghari, former MNA Abdul Hakeem Baloch, former MNA captain (retd) Muhammad Safdar, PTI leader Abdul Aleem Khan and others.
The accused are allegedly involved in inflicting heavy losses to the national exchequer through misuse of power, embezzlement and corruption.
Many of the politicians, including Khawaja Asif and Aleem Khan, are facing the charges of making suspicious transactions and having assets beyond their known income.
Former Vice Chancellor Punjab University Dr Mujahid Kamran is also on the list of the accused.